Reports of Severe Liver Injury Associated
with RZ Treatment of LTBI
October 2000 – May 23, 2002
• 40 *cases (17 jurisdictions)
– 32 hospitalized
–   8 fatal
– 33 investigated
• 96 other reports of liver injury
  * A case is defined as a person who was hospitalized or died due to
    liver injury associated with RZ.