| Risk
of TB Disease by Time of M. tb Infection |
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| • | Among 1,472
persons enrolled in the placebo arm of 2 trials |
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| of the
efficacy of LTBI (Ferebee SH. Adv
Tuberc Res. 1970) |
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| – | 19
developed TB in 1st yr of follow-up (FU) |
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| – | 7
developed TB in subsequent 7 yrs of FU |
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| – | Difference
in case rate 12.9 vs 1.6 per 1,000 person-yrs |
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| • | Among 2,550
British children enrolled in the unvaccinated |
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| arm of TB
vaccine study (Sutherland I. TSRU
Prog Rep. 1978) |
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| – | 121 (5%)
developed TB in 15 yrs of FU |
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| – | Of
these, 54% cases during 1st yr, 82% within 2 yrs |
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