Toxicity of Isoniazid in Persons
Without HIV Infection
• Hepatitis 10.3/1000 persons
• Death due to hepatitis 0.6/1000 persons
• Age-related hepatotoxicity
35 years   0.6-1.3/100 persons
> 35 years   2.0-3.1/100 persons
• Risk factors
Active liver disease, Alcohol
• Mortality risk associated with pregnancy,
Hispanic ethnicity