Osteogenesis imperfecta
 (brittle bone disease)
• Type II :
•  Most severe form, frequently lethal at or shortly
after birth, often due to respiratory problems.
• In recent years, some people with Type II have
lived into young adulthood.
• Numerous fractures and severe bone deformity;
small stature with underdeveloped lungs.
• Collagen is improperly formed.