Enzymes cont.
• the presence of inhibitors.
– competitive inhibitors are molecules that bind to the
same site as the substrate - preventing the substrate
from binding as they do so - but are not changed by the
enzyme.
– noncompetitive inhibitors are molecules that bind to
some other site on the enzyme reducing its catalytic
power.
• pH. The conformation of a protein is influenced by pH and
as enzyme activity is crucially dependent on its
conformation, its activity is likewise affected.