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| Session
5: Mechanisms and Consequences of |
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| Chemical
Exposures - Graziano |
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| • | Dose
response curves, concept of LD 50, theshold |
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| / no
threshold response |
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| • | Net
effect of absorption distribution and |
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| elimination
on concentration of drug/toxin in body |
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| • | Individual
variation in drug/ toxin metabolism due |
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| to
variations in liver enzymes (cytochrome P450 |
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| family
- Induction and inhibition of liver enzymes |
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| may
increase or decrease drug effect respectively. |
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