Cohort Epidemiology
• Address long-term exposure-response window
• Large populations in multiple cities enrolled
and then followed for many years to determine
mortality experience
• Cox proportional hazards modeling to
determine associations with pollution exposure
• Must control for spatial confounders, e.g.,
smoking, income, race, diet, occupation
• Assessment of confounders at individual level is
an advantage over cross-sectional, “ecologic”
studies