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| Dopamine Function is Deficient in Major |
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| Depression |
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| • | Parkinson’s
Disease associated with depression. |
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| • | CSF
shows low homovanillic acid (HVA). |
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| • | Neuroendocrine
challenges: blunted responses to dopamine |
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| agonists |
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| • | Depletion
of dopamine with AMPT causes depression in |
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| recovered
patients but not normals. |
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| • | Imaging:
nothing found yet. |
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| • | Postmortem
brain: no data |
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| • | Genes:
TH, COMT & MAO |
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