Less Serotonin Transporter and Gene
Expression
• Less SERT binding could be a consequence of less
gene expression (cause or regulation).
• Less SERT binding could be a consequence of
more SERT internalization due to less intra-
synaptic SERT.
• This effect would augment serotonin action.
• Is low SERT and gene expression compensatory
or just part of pathogenesis?