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| • |
Stress
hormones cortisol and CRF are elevated in blood
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or
CSF of suicide attempters of future suicides.
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| • |
Fewer
prefrontal CRF receptors in suicide victims suggest
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excess
CRF release.
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| • |
Evidence
in brain of suicides of more NE release (more
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tyrosine
hydroxylase and beta-adrenergic desentization ).
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| • |
Abuse
history in childhood associated with excessive adult
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stress
responses in terms of both cortisol and NE.
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| • |
Fewer
noradrenergic neurons in depressed suicides means
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lower
functional capacity and prone to NE depletion.
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| • |
Low
norepinephrine may favor
more pessimism.
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