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| PET Measures of PFC Activity and |
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| Depression
or Suicidal Behavior |
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| • | Widespread
altered activity in the PFC is associated with |
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| depression. |
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| • | Localized
medial PFC hypo-function in suicide attempters |
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| is
proportional to the medical lethality of the most
lethal |
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| life-time
suicide attempt. |
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| • | The
activity in this brain region is independent of the |
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| objective
severity of the depression, but is related to |
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| impulsivity
and suicidal intent. Thus, it can influence |
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| suicidal
behavior. |
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