Evidence for Hormonal Effects
on Mood in Affective Illness
1. Unipolar syndromes occur during drops in
estrogen/progesterone:
• Premenstrual
• Postpartum
• Perimenopausal
2. Iatrogenic affective symptoms:
• HRT lowers depression scores.
• Affective symptoms have been associated with
OCP and GnRH agonists.
Women and Bipolar Disorder