| Neuregulin
(ARIA) |
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| • | Acetylcholine
receptor inducing activity |
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| • | Expressed in
motor neuron and in muscle |
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| • | Binds and
activates receptor tyrosine |
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| kinases on the
muscle (erbB2, erbB3, |
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| erbB4) |
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| • | Signals through
MAP-kinase pathway |
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| • | Leads to
upregulation of ACh-R expression |
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| in sub-synaptic
nuclei |
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