Drug Induced Gingival
Enlargements
• Phenytoin
• Interdental papillae, may  be delayed eruption due the bulk of
fibrous tissue, ectopic eruption, withdrawal of drug will bring
about resolution in most cases.
• Tx - oral hygiene key in control of overgrowth, chlorhexidine
mouthwash, gingivectomy to allow for eruption and esthetics.
• Cyclosporin A
• H/o liver, kidney, heart and combined heart/lung transplants.
most commonly used med for anti-rejection, seen in about 30-
70% of these cases.
• Nifedipine and verapamil
• Both are calcium channel blockers, used to control cyclosporin
induced hypertension after transplants in children.
• Tx - oral hygiene and gingivectomy.
K. Kohli, DDS