| Why Calcium? |
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| • | Na+
and Cl- are sea water |
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| – | Excluded to
maintain low osmotic pressure |
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| – | [K+]i
kept high for electrical neutrality |
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| • | [Ca2+]i
maintained very low |
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| – | Prevents
precipitation of organic anions |
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| • | Mg2+
helps solubilize organic anions |
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