| Mechanism of action of antidepressants |
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| • | Change
of the setpoint of monoamine |
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| transmission |
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| • | Plastic
changes occurring in the limbic target |
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| areas
of monoaminergic projections (Hipp., |
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| Amy.,
Ctx) |
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| – | Halt
hippocampal atrophy |
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| – | Prevent
stress-induced dendritic shrinkage |
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| – | Increase
hippocampal neurogenesis |
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