A brief introduction to HD (2):
		• The HD gene, IT15 (HDCRG, 1993) • Promoter: house keeping gene? • Conserved to Fugu puffer fish • Gene KO studies – Nasir et al., Zeitlin et al., Duyao et al. • Gene product, huntingtin (htt) • Large protein in complex • Function: unknown • Ubiqutious expression • Cleavage by calpain and caspase-3