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Myogenic tone
refers to the ability of vascular smooth muscle to alter its state of
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contractility in
response to changes in intraluminal pressure
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The vessel
constricts in opposition to an increase in intravascular pressure and
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dilates when the
pressure decreases
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Behavior
observed in a variety of vascular tissues, including veins and conduit
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arteries, but
especially prevalent in resistance vasculature.
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Classically
described as being a Ca2+ dependent process where pressure
evoked
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depolarization
and Ca2+ entry through voltage gated Ca2+ channels
play
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obligatory roles
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Consistent with a
role for pressure-induced depolarization, blockers of voltage
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gated Ca2+
channels have been shown to reduce myogenic responses.
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