• Molecular evidence suggests that store-operated and receptor-operated channels may be formed from proteins belonging to the same family, being the mammalian homologues of the transient receptor potential (TRP) channels. • Less clear whether they form the channels in native smooth muscle • One putative model is that TRPC proteins may fall into two classes; one responsive to receptor activation but not store depletion and the other responsive to store depletion.
			McFadzean and Gibson  Br J Pharm 135: 1-13